Granites and related mineralization have been an important scientific issue of economic geologists. In the past a few decades, much progress have been made on the research of granitoid series and related metal commodities. It hosts a huge Mesozoic magmatic province containing abundant W-Sn-Mo-Cu-Pb-Zn mineralization in South China, but the scale of Cu-Pb-Zn deposits is relatively smaller than that of W-Sn deposits. Based on the review on classification and metallogenic specialization of granites, the paper discusses spatial and temporal distribution of Mesozoic syntexis type granite-related Cu-Pb-Zn mineralization in South China, the characteristics of syntexis type granite, magma source, and its relationship to re-melting of the ancient crustal materials. This paper argues that the source magma of syntexis type granite is closely associated with Cu-Pb-Zn mineralization. The size of ore, such as, the scale of copper is associated with the proportions of mantle contribution, but the lead-zinc mineralization is primarily related to the contribution of crustal materials. There is also difference of mantle contributed to the copper mineralization in the different ore-concentrating district. The paper concludes that the Mesozoic syntexis type granite is characteristics of transition type granites between typical porphyry copper deposit-related and W-Sn deposit-related, the Cu-Pb-Zn mineralization was resulted from the re-working of ancient crustal materials, in South China.