知识与财富的链接
从色钉菇Chroogomphus rutilus子实体中分离纯化出11种化合物,经核磁等方法鉴定为：（1）麦角甾-7,22-二烯-3-酮;（2）麦角甾-4,6,8(14), 22-四烯-3-酮;（3）邻苯二甲酸二丁酯;（4）顺式-3-己烯醇;（5）3β,5α,6β-三羟基麦角甾-7,22-二烯;（6）α-甜没药醇;（7）2-甲氧基腺嘌呤核苷;（8）(4E,8E)-2-N-(2-羟基棕榈酰)-1-O-B-D-吡喃葡萄糖基-9-甲基-4, 8-sphingadienine;（9）5-羟基尿嘧啶核苷;（10）2-氨基-3-醛基-6-甲氧基吡啶;（11）Polyozellin。对分离化合物的体外抗氧化、抗肿瘤活性的初步测定结果显示,2-甲氧基腺嘌呤核苷、顺式-3-己烯醇表现出较强的清除DPPH自由基活性,EC50值分别为0.06128mg/mL和0.08253mg/mL。5-羟基尿嘧啶核苷对人胃癌细胞株BGC的增殖有较强的抑制作用,IC50值为7.92μg/mL。研究结果为进一步开发利用色钉菇提供了科学依据。
Eleven compounds were isolated from fruiting bodies of Chroogomphus rutilus. They were identified as ergosta-7,22-dien-3-one (1), ergosta-7,22-dien-3-one (2), dibutyl phthalate (3), cis-3-hexenol (4), cerevisterol (5), α-bisabolol (6), 2-methoxyadcnosine (7), (2S,3R,4E,8E,2’R)-2-N-(2’-hydroxy-palmitoyl)-1-O-B-D-gluco-pyra-No-syl-9- methyl-4,8-sphingadienine (8), 5-hydroxyuridine (9), 2-amino-3-formyl-6-methoxypyridine (10), and polyozellin (11). The preliminary analysis of antioxidant and anti-tumor activities of the compounds indicated that 2-methoxyadcnosine and cis-3-hexenol revealed the higher capacity on scavenging DPPH free radical with EC50 value of 0.06128mg/mL and 0.08253mg/mL. Moreover, 5-hydroxyuridine could strongly inhibit the BGC cell line proliferation with IC50 value of 7.92μg/mL. These results provided scientific basis for the development and utilization of C. rutilus.
