War trauma accompanied by multidrug-resistant infection pose a severe challenge for military medical services. Due to the wide application of antibiotics, war trauma complicated by multi-drug resistant infection is becoming a troublesome problem. This paper summarized the commonly-seen war-related bacteria and the corresponding revolution of drug resistance. The details of detection, treatment, and prevention measures of multi-drug resistant bacteria in war trauma were reviewed, and the risk factors of multi-drug resistance in warfare condition was also discussed.