This study focused on Tuojiang River from Deyang to Luzhou, Sichuan. Samples were collected from twenty-five sampling points during high flow period (July-September). Analysis on distribution of Bisphenol A(BPA),Estrone(E1),17α-Estradiol(E2),Estriol(E3),17α-Ethinylestradiol(EE2) by ultra-performance liquid chromatography tandem mass spectrometry (ESI+).The results show that: BPA and NP were be detected in Tuojiang River. The concentrations of BPA were from 3.93 ng/L to 198 ng/L in this area and it was medium level compared with the areas at home and abroad. The concentrations of NP were from 5.23 ng/L to 150 ng/L in this area and it was similar with the areas abroad, lower than home. The concentrations of the pollutants were higher in the north part and lower in the south part. The samples from the upstream sites had prominently higher concentrations than those from mid-stram or downstream sampling sites, and the mains tram was lower than tributaries.