Objective To observe the effect of lidocaine aerosol on preventing cardiovascular response and sore throat, hoarseness in the patients with double lumen tube to orotracheal intubation. Methods 60 selective patients (ASAⅠ-Ⅱ) scheduled for lung lobectomy were randomly divided into 3 groups, with 20 cases in each group. Lidocaine aerosol (group A) and Saline as a control (group B and group C) were given to spray. After routine induction, the glottis was exposed and 3 press lidocaine aerosol were given in group A, while group B and C were given saline. Patients in group C were received additional 0.5mg/kg of propofol and 1μg /kg of fentanyl intravenously before the exposure of glottis. HR, SBP, DBP, HR*SBP were monitored and recorded at the time points of pre-induction (T0), immediately pre-intubation (T1), 1 min (T2), 3 min (T3), 5min (T4) , 10min(T5) after intubation. Cases of sore throat and hoarseness were also recorded at the point of 1h, 6h, 24h postoperation. Results Compared with T0, values of HR, SBP and RPP at T1 were significantly decreased after induction（P<0.05）. Values of HR, SBP ,RPP in group B and C were higher than that in group A at T2 and T3（P<0.05）. SBP was significantly decreased at T4 and T5 in group C（P<0.05）.Cases of postoperative sore throat and hoarseness in group A were significantly lower than that in group B and C（P<0.05）. Conclusion Lidocaine aerosol can effectively suppress cardiovascular responses caused by double lumen tube intubation, decrease the dose of induction drugs, reduce the incidence of postoperative sore throat and hoarseness.