知识与财富的链接
目的 探讨CD38、CD138在慢性子宫内膜炎病理诊断中的应用及临床意义.方法 从2012年1月-2013年7月在我院诊治的1116例异常子宫出血患者中随机选取154例作为研究对象,根据HE染色结果将其分为A组（慢性子宫内膜炎确诊组）21例、B组（慢性子宫内膜炎疑似组）103例和C组（非慢性子宫内膜炎组）30例.比较3组活检组织中免疫组化染色CD38、CD138浆细胞表达情况.结果 子宫内膜组织CD38浆细胞表达情况：A组阳性率为100.0%,B组阳性率为65.0%,C组阳性率为0.6%;子宫内膜组织CD138浆细胞表达情况：A组阳性率为100.0%,B组阳性率为37.9%,C组阳性率为0.6%.3组子宫内膜组织CD38和CD138阳性率比较,差异均有统计学意义（P＜0.05）.结论 疑似慢性子宫内膜炎标本,在HE染色中浆细胞无法辨认时,应用CD38、CD138进行免疫组化染色可有效显示子宫内膜中的浆细胞,明显提高慢性子宫内膜炎的确诊率.
Objective To explore the application and clinical significance of CD38 and CD138 in pathological diagnosis for chronic endometritis. Methods 1116 patients with abnormal uterine bleeding admitted to our hospital from January 2012 to July 2013 were enrolled, thereinto 154 cases were randomly selected as research subjects. According to the results of HE, the 154 patients were divided into group A （confirmed chronic endometritis, n = 21 ） , group B （suspected chronic endometritis, n = 103） , group C （without chronic endometritis, n = 992）. Expressions of CD38, CD138 in biopsy specimens of the three groups were compared. Results CD38 expression of plasma cells in endometrial tissues： 100% in group A, 65% in group B, 1.2% in group C; CD138 expression of plasma cells in endometrial tissues： 100% in group A, 37.9% in group B, 0. 6% in group C. There were statistically significant differences in positive rate of CD38 and CD138 in endometrial tissues in the three groups （P 〈 0. 05 ）. Conclusion The application of CD38, CD138 can effectively display endometrium plasma ceils when it is illegible of plasma cells in HE staining that specimens suspected as chronic endometritis, improve the diagnosis rate of chronic endometritis.