According to the connotation and denotation of grand interaction design in big data information era,it outlines an exploration into the development of interaction design through analyzing and predicting the grand interaction design trend,methodology,process,information architecture,paradigm,prototype and usability evaluation in big data information era. It provides the grand interaction design strategy and principles through the outcomes of big data analysis, user study,PETSC(politics,economy,technology, society, culture) study, case study of web interaction design, mobility interaction design and gameplay interaction design. It demonstrates the new performances which include non-causality, non-continuity,volatility,unpredictability,eco-system reference system for brand interaction design through the comparative study of quantum management. It expounds the four functions of "information exchange value", "interface communication media","function interactive means" and "contents transportation evaluation" for interaction design on the five levels of strategy,scope,structure,framework and presentation,proposes the information thinking which combines Newton Thinking and Quantum Thinking for "meaning-centered design" eco system grand interaction design method with the consideration of interactive perception context logic and information cognitive conscious emotion in a sustainable way.