In order to accurately evaluate reservoir stress sensitivity of gas fields in Huangliu Formation of the Dongfang 13 area in Yinggehai basin, stress sensitivity evaluation experiment, which was simulated with constant confining pressure and variable internal pressure during the development of gas reservoir, is elaborately designed. The experimental results show that permeability of samples decreases with the increase of net stress by the exponential law. Impairment rate stress sensitivity makes on reservoir permeability is between 7.58FfFf～46.1FfFf and the damage degree is generally weak-mid weak, which has some distinction between different samples. Analysis of petrologic mineral compositions, corrosion and cementation illustrates that: (1) Impairment rate reservoir stress sensitivity makes on reservoir permeability has a negative correlation with the content of rigid mineral quartz in clastic sandstone, if the quartz has a higher content and takes a larger proportion of total amount of debris, the impairment rate will be weaker. (2) Framework grains developed in dissolved intra-grain pores is easier to have structural collapse or deformation, which can damage reservoir permeability; however, reservoir with strong cementation has a less possibility to produce displacement or deformation for framework grains, therefore the reservoir stress sensitivity damage can be weaker.