Objective To investigate the quality stability of catalpol and verbascoside in small package of Chinese medicine pieces of Rehmannia glutinosa. Methods According to the content detection method in Chinese Pharmacopoeia (2005 edition), the different factors (high temperature, high humidity and strong light) were analyzed firstly, and then the accelerated experiment and long-term experiment were used to investigate its quality and stability. Results The content of catalpol was significantly decreased under high temperature. The quality and stability of small package pieces of Rehmannia glutinosa in vacuum packaging was better than that in conventional packaging. Under the conditions of 25 ℃ and RH 60%, the small package of Chinese medicine pieces of Rehmannia glutinosa was valid for 6 months. Conclusion The study can provide the basis for the preservation condition and validity period of small package of Chinese medicine pieces of Rehmannia glutinosa.