An energy-consumption balancing routing protocol based on regions is proposed to balance the energy consumption of wireless sensor network and enhance the network stability. The protocol designs an optimized region-divided algorithm which divides sensor nodes into clusters based on the regions to solve the random problem of clus-ters'number and distribution in previous protocols. In selecting clusters,a three-level selectional mechanism of clus-ter heads is adopted after taking consideration the factors of the residual energy of sensor nodes,the cluster topology and the internal total energy consumption of cluster. In forwarding the data,general nodes can choose the nearest cluster head which can select the next hop one in a two-upper level within the threshold of communication distance. Simulation results suggest,compared with DREEM-ME and MEET protocols,the proposed protocol can better bal-ance the nodes'energy consumption,enhance the network stability and improve the quality of network service.