Based on the current development of the desalination industry in China, the characteristics of desalination industry in the coastal regions of Bohai Rim Area, Yangtze River Delta and Pan-Pearl River Delta and the existing problems are analyzed. The factors such as regional distribution and industrial development are considered for the large-scale regional development. The relevant suggestions are put forward for the regional development of the seawater desalination industry in terms of the desalinated seawater to municipal water distribution system, brand establishment and island classification demonstration.