知识与财富的链接
目的 动态监测咸阳市健康人群麻疹抗体水平,并对麻疹相关疫苗的免疫效果进行流行病学评价。方法 2012-2015年,随机抽取咸阳市1 135例健康人群,采用酶联免疫吸附试验（enzyme-llinked immunosorbent assay,ELISA）检测麻疹抗体光密度（optical density,OD）值;并收集调查对象的免疫史情况,采用Logistic回归对麻疹相关疫苗进行流行病学评价。结果 2012-2015年调查对象的麻疹抗体OD值随年份略有下降趋势,在男女之间差异均无统计学意义（均有P>0.05）,OD值在2~3岁最高,随年龄增长有下降趋势;2012-2015年咸阳市健康人群麻疹抗体阳性率分别为：98.91%、96.81%、96.46%、85.11%;经Logistic回归分析,麻疹疫苗和麻腮风疫苗联合使用及麻疹疫苗单独使用对机体均具有明显的保护作用（麻疹疫苗+麻腮风疫苗+：OR=0.123,95% CI：0.046~0.328;麻疹疫苗+麻腮风疫苗-：OR=0.109,95% CI：0.043~0.281）。结论 咸阳市健康人群中虽已建立起免疫屏障,但麻疹抗体监测及查漏补种工作仍不能松懈;麻疹疫苗是基础疫苗,对麻疹抗体的形成是必要的,麻腮风疫苗可作为强化疫苗,不能单独使用。
Objective To dynamically monitor measles antibody among healthy people and to conduct an epidemiological evaluation of immune effects of measles related vaccines in Xianyang, 2012-2015. Methods A total of 1 135 healthy people were randomly selected in Xianyang and Enzyme-Llinked Immunosorbent Assay (ELISA) was used to detect OD values of measles antibody. Meanwhile, immunization history was collected to survey their immunization situation. Logistic regression was used to conduct an epidemiologic evaluation of measles related vaccines. Results The OD values of measles antibody decreased but there was no significant difference (all P>0.05) between different genders. The positive rates of measles antibody among healthy subjects in Xianyang from 2012 to 2015 were 98.91%, 96.81%, 96.46% and 85.11%, respectively; Logistic regression analysis showed that measles vaccine had a significant protective effect (measles + MMR vaccine +: OR=0.123, 95% CI: 0.046-0.328; measles vaccine + MMR vaccine-: OR=0.109, 95% CI: 0.043-0.281). Conclusions Although measles immune barrier among healthy people in Xianyang has been established, measles antibody monitoring still need to be strengthened; measles vaccine is the necessary basis for the establishment of measles antibody. MMR vaccine can be used to strengthen the vaccine but it is better not be used alone.
