Objective To study the effect of Helicobacter pylori （Hp）infection on plasma lipid and carotid-intima media thickness in healthy people and to explode its pathogenesis. Methods Status of Hp infection, lipid profile, plasma high-sensitivity C reactive protein （hs-CRP）, body mass index （BMI）, and carotid artery intima-media thickness（CIMT） were assessed in 244 subjects undertaken routine health examination. The lipid profile and carotid artery intima-media thickness in Hp positive and Hp negative groups were analyzed. Results Of the 244 cases,Hp infection occurred in 108 cases, the Hp infection rate was 44.26%. Hp infection had no relation with sex and age. Total cholesterol （TC）, triglyceride （TG）, apolipoprotein B （ApoB）were higher in Hp positive group than in Hp negative group, but not reaching statistical significance （ P〉0.05 ）. While high density lipoprotein cholesterol （HDL-C）, lipoprotein-a[Lp （a）], plasma hs- CRP were significantly lower in Hp positive group than in Hp negative group （P〈0.01）. Low density lipoprotein cholesterol （LDL-C）was obviously higher in Hp positive group （ P=0.023 ）. No significant difference in BMI was found between the two groups. CIMT in Hp positive group was significantly higher than that in Hp negative group （P〈0.01）. Conclusions By influencing lipid metabolism, Hp infection might aggravate the inflammatory reaction of vessel wall and promote the development of atherosclerosis.