知识与财富的链接
1-金刚醇和4-溴苯酚经付-克反应、酚羟基甲基化得到的2-（1-金刚烷基）-4-溴苯甲醚，与6-溴-2-萘甲酸甲酯经双金属催化交叉偶联、皂化反应制得阿达帕林，总收率67％。
Adapalene was synthesized from 1-adamantanol and 4-bromophenol by Friedel-Crafts reaction and methylation with dimethyl sulfate to give 2-(1-adamantanyl)-4-bromoanisole, which subjected to a novel double metal catalyzed coupling reaction with methyl 6-bromo-2-naphthoate and then saponification with an overall yield of 67 %.
