知识与财富的链接
Large amount of facts indicated that enantiomers were different from each other in biological activity, physiological activity and toxicity in clinical applications1. It resulted in the increase of interest on preparation of chiral drugs. Optical active 3-phenylglycidic ester, especially (2R,3S)-methyl 3-phenylglycidate is an important starting material for production of many chiral drugs, such as taxol, (2R,3S)-diltiazem etc2,3.For the above purpose, a series of lipases were screened. Final…
The enzymatic resolution of racemic methyl 3-phenylglycidate was investigated. It was found that the hydrolysis rate of (2S, 3R)-enantiomer was faster than that of (2R, 3S)-enantiomer by a new lipase. At optimal condition 96% of (2R, 3S)-methyl phenylglycidate with ee of 100% was recovered from the racemic mixture.
