SIR, We read with interest Whittle and Hughes's review concerningmethotrexate (MTX) and supplementation with folate in the treatmentof rheumatoid arthritis (RA), in which concomitant folate administrationis demonstrated to be useful to reduce MTX adverse effects,as proven in numerous trials [1]. Nevertheless, there are conflictingopinions on the real benefits of folate supplementation andno guidelines exist regarding doses and timing of its use [1].In our opinion, low doses of MTX, without concomitant