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An efficient and simple aminobenzannulation reaction: pyrrolidine as a trigger for the synthesis of 1-amino-acridines

ISSN:1523-7060
2005年第7卷第9期

[reaction: see text] A new aminobenzannulation methodology has been developed and applied successfully to the synthesis of 1-amino-acridines. The key and last step goes through an enamine intermediate that was detected in some cases. When pyrrolidine and powdered 4 A molecular sieves were used, the enamine synthesis and the aminobenzannulation step took place subsequently, whereas for other secondary amines, neutral Al(2)O(3) or PtCl(2) catalysis was necessary.

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ISSN:1523-7060
2005年第7卷第9期

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